RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
Sod2
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
rattus norvegicus
Detection Methods
EPR; Amplex red; Immunofluorescence etc.
Target
NA
Pathway
NA
PubMed ID
Title
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target
Year
2010
Function
"SOD2 expression in PASMCs is decreased in PAH patients and fawn-hooded rats (FHRs) with PAH.Genomic bisulfite sequencing demonstrates selective hypermethylation of a CpG island in an enhancer region of intron 2 and another in the promoter. Differential methylation occurs selectively in PAs versus aortic SMCs and is reversed by the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine, restoring both SOD2 expression and the ratio of proliferation to apoptosis. Expression of the enzymes that mediate gene methylation, DNA methyltransferases 1 and 3B, is upregulated in FHR lungs. Tissue-specific, epigenetic SOD2 deficiency initiates and sustains a heritable form of PAH by impairing redox signaling and creating a proliferative, apoptosis-resistant PASMC. SOD augmentation regresses experimental PAH."